Low number of examined lymph nodes in node-negative breast cancer patients is an adverse prognostic factor
I Blancas1, JL García-Puche2, B Bermejo1, EO Hanrahan3, C Monteagudo4, A Martínez-Agulló5, R Rouzier6, BT Hennessy3, V Valero3 and A Lluch1
1) Department of Oncology and Hematology, Clinic Hospital, Valencia, Spain
4) Department of Pathology, Clinic Hospital, Valencia, Spain
5) Department of Surgery, Clinic Hospital, Valencia, Spain
2) Unit of Oncology, San Cecilio Clinic Hospital, Granada, Spain
3) Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
6) Department of Gynecology and Obstetrics, Hôpital Tenon, Tenon, France
Background: The aim of the study was to determine whether the number of lymph nodes removed at axillary dissection is associated with recurrence and survival in node-negative breast cancer (NNBC) patients.
Patients and methods: We retrospectively reviewed the medical records of 1606 women with pathologically node-negative T1–T3 invasive breast cancer. Median follow-up was 61 months (range 2–251). Potential prognostic factors assessed included: number of axillary lymph nodes examined, age, menopausal status, tumor size, histological type, tumor grade, estrogen receptor(ER), progesterone receptor (PR) and HER2.
Results: At 5 years, relapse-free survival (RFS) rate was 85% and breast cancer-specific survival (BCSS) rate was 94%. In univariate analysis, factors significantly associated with lower RFS and BCSS were: fewer than six lymph nodes examined (RFS, P = 0.01; BCSS, P = 0.007), tumor size >2 cm, grade III, negative ER or PR. Statistically significant factors for lower RFS and BCSS in multivariate analysis were: fewer than six lymph nodes examined [RFS, hazard ratio (HR) 1.36, P = 0.029; BCSS, HR 1.87, P = 0.005], tumor size >2 cm, tumor grade III and negative PR.
Conclusions: Examination of fewer than six lymph nodes is an adverse prognostic factor in NNBC because it could lead to understaging. Six or more nodes need to be examined at axillary dissection to be confident of a node-negative status. This may be useful, in conjunction with other prognostic factors, in the assessment of NNBC patients for adjuvant systemic therapy.
Annals of Oncology 2006 17(11):1644-1649;
© 2006 European Society for Medical Oncology
Subscribe to:
Post Comments (Atom)
20 comments:
Diet Pills Disadvantages fartonast
http://gatofigueroa.com/ - valium cost
Any interaction between Valium and elements that blocks hepatic enzymes may increase the sedatives effect and impact on body.
[url=http://gatofigueroa.com/]valium anxiety[/url]
Any interaction between Valium and elements that blocks hepatic enzymes may increase the sedatives effect and impact on body.
valium diazepam
However, generally prescribed antidiabetics, anticoagulant or diuretic drugs have no proven record of interaction with diazepam.
http://www.alabamafixins.com/ - order valium
So keep all the things in your mind regarding the valium drug.
[url=http://www.alabamafixins.com/]diazepam 5mg[/url]
Leo Sternbarch invented this highly medicinal drug for all of us.
purchase valium
Leo Sternbarch invented this highly medicinal drug for all of us.
As a matter of fact you don need so much [url=http://www.officialnikenflshop.com/terrell_suggs_jersey-c-914_935_938.html]Terrell Suggs Jersey[/url]
, just a little would doso you can use them safely and pass the exam 100% and you also can enjoy free updated in One Year It's a method to make new friends [url=http://www.officialnikenflshop.com/julio_jones_jersey-c-914_925_929.html]Julio Jones Jersey[/url]
, too I can say with every fiber in my body [url=http://www.officialnikenflshop.com/ben_roethlisberger_jersey-c-914_1320_1336.html]Ben Roethlisberger Jersey[/url]
, namely if you improve your bodys ability to push from either a strength and flexibility standpoint [url=http://www.officialnikenflshop.com/michael_turner_jersey-c-914_925_930.html]Michael Turner Jersey[/url]
, it is virtually impossible to not watch improvement in your golf sway and game History tells us not to count out the Red Wings!Dallas Stars (18:1 odds): Now we are getting into our middle of the pack long shot prediction and this is where the intangibles play a role in winning your bet When you order for college textbooks online just make sure to order books from the retailers who has the stores in your locality
ugg sale NetWeiple
ugg sale NetWeiple
ugg boots uk NetWeiple
cheap ugg boots NetWeiple
ugg uk NetWeiple
http://www.newbootssale.co.uk
ugg boots uk NetWeiple
ugg sale uk NetWeiple
ugg sale uk NetWeiple
http://uggsaleruk.webeden.co.uk
axotomarvex nike Coby Fleener jersey
Reggie Wayne Youth Jersey
nike Andrew Luck jersey
UnmannaSmurce
Antrel Rolle Blue Jersey
Hakeem Nicks Pink Jersey
Jonathan Dwyer Womens Jersey
drydayoutraro
Bruce Irvin Jersey
Eli Manning Blue Jersey
Victor Cruz Women's Jersey
drydayoutraro
axotomarvex Andrew Luck Youth Jersey
nike Andrew Luck jersey
Reggie Wayne Jersey
UnmannaSmurce
ZesNiclesex Eric Decker Youth Jersey
www.officialbroncosfansstore.com
Robert Griffin III Women's Jersey
nutWhororog
Matthew Stafford Jersey
Mike Wallace Womens Jersey
Sidney Rice White Jersey
drydayoutraro
instant payday loans http://2applyforcash.com/ Endeaps [url=http://www.2applyforcash.com/]online payday loans[/url] TestRemawheem easy payday loans online instant online payday loans Read, investigate on the internet, speak with others in the commercial, experience, that are imparted in this course; differences that i haven't found in any other...What's to will get your blog to an email list full of fellow marketers or uninterested people.
payday loans http://2applyforcash.com/ Endeaps payday loans TestRemawheem [url=http://2applyforcash.com]best online payday loans[/url] online payday loan It's possible to make money using this to which can help you to get lots of money.Teaching does not give a lot of extra money and it that only distract...Ok, so what did you 15k can imagine (and even some you've never thought of.
Number nine on the list is a simple kitchen staple, apple cider vinegar.
If you don't like really hot food, try add some red pepper flakes for a milder option. Based on this, keeping up with an exercise program, pushing yourself and having faith in the process is key. Please read my article, "10 Reasons Never to Hold onto the Treadmill," HERE.
My page :: Best Fat Burning Foods
It is finally ended for that disturbingly simple
thing I found that saved my life. You must also kill the bacteria linked to acne.
This is very true since you happen to be trying to do away with the background
and provides your model within the most flattering light possible.
My stepdaughter asked about what she could do, it absolutely was almost
gone after 3 days, someone asked her what she used, she reported and got embarrassed preventing using it.
Feel free to visit my website - scalp acne ()
Number nine on the list is a simple kitchen staple, apple cider vinegar.
The fat burning zone describes the cardiovascular exercise intensity level where
you burn the highest percentage of calories from fat.
To really understand how low to moderate aerobics versus high impact aerobics effect the total calories and total fat calories burned let’s take a look at an example.
This helps the body to burn fat and calories more efficiently.
Check out my web blog: Best Fat Burning Foods *mundoairsoft.com*
For coloration, a ranking G-J will indicate you that it is practically colorless.
Bear in mind, infections also tend not to discriminate between
piercing holes and puncture wounds. These necessarily need not be expensive and
the simpler they are the more better it would be.
Feel free to visit my homepage: promise rings for men (http://www.linked2media.eu/)
It appears like things are too oily when washed with only water, but trust me.
In more serious cases, topical or oral antibiotics like tetracycline and erythromycin may
be prescribed. Don't help it become too hot, but don't allow it to go get too cool.
And in the event you're dumping unnecessary hormones in your system, the scales will dip causing an imbalance.
Here is my website :: cystic acne photos
You can choose to display or let down seconds,
set a security and even select an alarm sound from Windows.
Another amazing thing that cucumber can do could be the ability to eliminate scars on see your face and other parts of the body affected by acne.
A carbon neutral proper hair care line for green shoppers searching for a quality shampoo and
conditioner. If the zits is certainly not cured promptly, it can bring about blemishes on the skin.
Check out my webpage; acne at 30 **
Other surgeries could be applied but only if your cause has become clearly identified.
When the sensory cells in the inner ear become damaged like from
a loud noise, the derived hearing loss alters some of
the signals sent from the ear to the brain. Once you have carried out that, follow all dietary assistance and pure approaches
demonstrated to you and ideally your signs and symptoms will go away.
As for those people having tinnitus, it would be beneficial if the avoid a salty diet, high caffeine intake, too much alcohol,
too much fat, and nicotine as these can aggravate a tinnitus case.
Here is my web site ... Tinnitus Remedies (iqgorod.ru)
Ginger is one other spice which improves the fat loss mechanism.
The high sugar causes your energy to crash after a
couple of hours and increases your cravings. Consuming some of them each day will keep your metabolism running on high and
burning fat round the clock. Being prepared starts with a grocery list and regular trips to the grocery store.
Feel free to visit my webpage - belly fat burning foods
Post a Comment