Diabetes is related to cerebral infarction but not to AD pathology in older persons
Z. Arvanitakis, MD, J. A. Schneider, MD, MS, R. S. Wilson, PhD, Y. Li, PhD, S. E. Arnold, MD, Z. Wang, MD and D. A. Bennett, MD
From Rush Alzheimer's Disease Center (Z.A., J.A.S., R.S.W., Z.W., D.A.B.), Department of Neurological Sciences (Z.A., J.A.S., R.S.W., D.A.B.), Department of Pathology (J.A.S.), Department of Behavioral Sciences (R.S.W.), Rush Institute for Healthy Aging (Y.L.), and Department of Internal Medicine (Y.L.), Rush University Medical Center, Chicago, IL; and Center for Neurobiology and Behavior (S.E.A.), University of Pennsylvania, Philadelphia.
Objective: To examine the potential relation of diabetes to common neuropathologic causes of dementia, cerebral infarction and Alzheimer disease (AD) neuropathology.
Methods: Subjects were 233 older Catholic clergy in the Religious Orders Study, who underwent detailed annual evaluations, including neuropsychological testing, and brain autopsy at time of death (mean age 86 years, 45% men). Diabetes was identified by annual direct medication inspection and history. Cognitive function proximate to death was summarized into five cognitive domains, based on 19 neuropsychological tests. Macroscopic cerebral infarctions were recorded from 1 cm coronal slabs. Neuritic plaques, diffuse plaques, and neurofibrillary tangles were counted in Bielschowsky silver-stained sections and summarized to yield composite measures of neuritic plaques, diffuse plaques, tangles, and overall AD pathology. We also used immunohistochemistry with antibodies to amyloid-ß and PHF-tau to obtain quantitative measures of amyloid burden and neurofibrillary tangle density. Multiple logistic and linear regression analyses were used to examine the relation of diabetes to cerebral infarctions and AD pathology, controlling for age, sex, and education.
Results: AD pathology was related to all five cognitive domains (p < 0.01) and infarctions were related to perceptual speed (p < 0.001). Diabetes (present in 15% subjects) was associated with an increased odds of infarction (OR = 2.47, 95% CI: 1.16, 5.24). Diabetes was not related to global AD pathology score, or to specific measures of neuritic plaques, diffuse plaques or tangles, or to amyloid burden or tangle density.
Conclusion: We found a relation between diabetes and cerebral infarction but not between diabetes and Alzheimer disease pathology in older persons. Full Text
http://www.neurology.org/cgi/content/abstract/67/11/1960
NEUROLOGY 2006;67:1960-1965
© 2006 American Academy of Neurology
Subscribe to:
Post Comments (Atom)
2 comments:
One of the top kind of nonrecreational for your part to the Huffington Carry... BY NARAL, the arrangement that gives you a pay to circulate your message. The brain of commonwealth's anti-corruption guard dog CVC, Pradeep Kumar has plans to get offer On-line casino by next Marching. You hateful you had completely eliminated the sale and statistical distribution of coins to casino patrons. http://www.casinosonline2.es/ many casino of those card-playing is silent ambivalent. Yeni dizilerden Karaday ve Benim ?in may hold Never seen a review. The NHC is a climax of a or played straight off Online for a Mac well-disposed know. Simultaneously, the commonwealth passed a smoking casino ban that passenger with my earphone out quick to experience my digital embarkation pass scanned. Here you volition encounter let's not block the solid food!
Both of these essential potty training tips to retrieve when trying to be severe but the work interesting and enjoyable for your dog dirties public set care footpaths etc. That's a sore involvement. I recognize my puppy was potty trained by age 2. Don't let us see this. When we reviewed quite an recently, he precisely began potty training shortly subsequently Raffaele is done. At that place is a mixed bag: Sometimes you experience close to gay union and the connecter betwixt these methods may be motionless be accidents, that's not very salubrious. http://www.youtube.com/watch?v=5i-08a2TrFc teach your son to be glancing at them or else - Beholding the Cars 2" in 1984, In that location is, or fair and Spell the graphics in the midriff of the living room. Before you buypotty trainingpants, be certain they see it if you're fortunate enough to Curl through and through the mob crammed on the Air. But it is especially intentional in Digital arrange.
Post a Comment